National PrEP Day2026 · Date · History · Messages
MISTR and SISTR announced the first National PrEP Day for October 10, 2025. Independent health-sector reporting corroborated the launch, and a September 2026 Illinois legislative release described October 10, 2026 as the second annual observance with MISTR again participating. Clinical context is kept independent through current CDC PrEP guidance.
About National PrEP Day
National PrEP Day is a private U.S. HIV-prevention awareness campaign observed on October 10.
MISTR and SISTR announced the first National PrEP Day for October 10, 2025; later 2026 material describes a second annual observance.
Why National PrEP Day matters
The campaign is intended to increase awareness of pre-exposure prophylaxis, or PrEP, as an HIV-prevention option and to encourage informed conversations about access and prevention.
Clinical information should come from independent public-health sources: CDC describes PrEP as medicine that reduces the chance of getting HIV for people without HIV who may be exposed.
History of National PrEP Day
MISTR and SISTR publicly announced the first National PrEP Day on September 30, 2025, setting the inaugural date as October 10, 2025.
Independent U.S. Business Action to End HIV reporting documented MISTR’s October 10, 2025 launch campaign.
A September 2026 Illinois legislative release described October 10, 2026 as the second annual National PrEP Day and said MISTR was again marking the day.
The campaign’s organizer claims and service promotions are kept separate from independent CDC clinical guidance.
How the observance developed
This timeline uses documented milestones from reviewed sources. Missing stages are left out rather than guessed.
MISTR and SISTR
Their September 30, 2025 first-party announcement says they were launching the first National PrEP Day.
MISTR and SISTR
MISTR/SISTR September 30, 2025 launch announcement
First documented observance
The first-party launch and independent Health Action report identify October 10, 2025 as the inaugural campaign day.
MISTR, with National PrEP Day campaign partners
A September 2026 Illinois legislative release describes MISTR as marking the second annual National PrEP Day.
What the evidence establishes
Confirmed institutional roles and milestones are shown first. Details that could not be established from the reviewed sources are listed separately below.
2 fields not established in reviewed sources
Also known as
National PrEP Day
How to Observe National PrEP Day
Read current PrEP information from CDC or another qualified public-health source.
If PrEP is personally relevant, discuss options, testing and follow-up with a qualified healthcare professional rather than relying on an observance page for medical advice.
Share general awareness resources without assuming or disclosing anyone’s HIV status, sexual orientation, sexual behavior or other private health information.
If organizing an awareness event, use medically accurate materials and avoid presenting a commercial telehealth service as the only route to care.
National PrEP Day Facts
National PrEP Day is observed on October 10.
The source-cleared first edition is October 10, 2025.
MISTR and SISTR are source-cleared as the launch organizers.
CDC describes PrEP as medicine that reduces the chance of getting HIV for adults and adolescents without HIV who may be exposed.
Whether PrEP is appropriate for a particular person is a healthcare decision; an awareness observance is not a substitute for clinical guidance.
National PrEP Day Messages
National PrEP Day can be a prompt to learn about HIV prevention while leaving personal medical decisions to individuals and their healthcare professionals.
Topic and context
What this page does not assume
- Keep the source-defined country, community, organizer or institutional scope; do not silently broaden it.
- Do not treat the title alone as proof of government recognition or public-holiday status.
- Do not add a creator, founding story or origin claim unless the supporting evidence establishes it.
- Health Information Not Medical Advice.
Evidence & sources
Sources used across the guide are gathered here. Labels show how each source supports the page, and contextual references are kept separate from primary evidence.
CDC — Preventing HIV with PrEP (clinical context only)
Illinois House Democratic Caucus release — second annual National PrEP Day, 2026
MISTR — first National PrEP Day launch
CDC — Preventing HIV with PrEP (opens in a new tab)
Independent Government Clinical Reference
Health Action — October 2025 Action Report (opens in a new tab)
Independent Health Organization
Illinois House Democratic Caucus — second annual National PrEP Day, 2026 (opens in a new tab)
State Legislative Release
MISTR — first National PrEP Day launch (opens in a new tab)
Original Organizer
U.S. Business Action to End HIV / Health Action — October 2025 Action Report
Understand it, compare it, then explore further
Start with the most common factual questions, then compare closely related observances and explore useful connections.
Frequently asked questions
When is National PrEP Day?
10 October The documented recurrence rule is: 10 October.
Does National PrEP Day fall on the same date every year?
Yes. It uses a fixed annual date unless stronger evidence changes the pattern.
Is National PrEP Day an official public holiday?
The reviewed sources verify it within this scope: United States / private HIV-prevention awareness campaign launched by MISTR and SISTR. That recognition does not by itself make it a statutory public holiday; the site only makes public-holiday claims when reliable evidence explicitly does so.
Who established or recognizes National PrEP Day?
The reviewed sources identify MISTR and SISTR as the proclaiming or establishing body. Current facilitation or coordination is recorded as MISTR, with National PrEP Day campaign partners.
Is National PrEP Day international or country-specific?
This observance is specific to United States. Its fuller verified scope is: United States / private HIV-prevention awareness campaign launched by MISTR and SISTR.
How is this page verified?
The factual information is checked against reviewed sources, including the date pattern, scope and institutional history. This page was checked on 2026-09-26.
When is National PrEP Day?
It is observed on October 10.
When did National PrEP Day begin?
MISTR and SISTR announced the first National PrEP Day for October 10, 2025.
What is PrEP?
CDC describes PrEP, or pre-exposure prophylaxis, as medicine that reduces the chance of getting HIV for people without HIV who may be exposed.
Does this guide recommend a particular PrEP service or treatment?
No. It provides observance history and links to independent public-health information; individual medical decisions belong with qualified healthcare professionals.
Other observances on October 10
These observances are also listed on October 10, 2027.
Anniversary of the Beginning of the Wars of Independence
Cuba’s official tourism portal lists 10 October as the Anniversary of the Beginning of the Wars of Independence and identifies it as a national commemoration date.
Curaçao Day
Curaçao’s official tourism organisation promotes 10 October celebrations explicitly as Curaçao Day, while a U.S. State Department message independently recognizes the observance on that dat…
International Stage Management Day
The Association of British Theatre Technicians, describing its Stage Management Association partner, states that International Stage Management Day is on 10 October each year.
National Day of the Republic of China (Taiwan)
Current Taiwan government holiday information lists October 10 as National Day, and Presidential Office historical material connects the date to the Wuchang Uprising of October 10, 1911.
Pastor Appreciation Day
Focus on the Family currently marks the second Sunday in October as Clergy Appreciation Day within October’s clergy/pastor appreciation tradition; exact creator claims for the named day rem…
White Sunday
Samoa Tourism explains White Sunday as a major Samoan children’s and church observance; official mission calendars document the adjacent 2026 holiday observance.